A description of the neurodevelopmental hypothesis of schizophrenia

Neurodevelopmental hypothesis of the etiology of schizophrenia

Preschizophrenic children have a higher incidence of: neuromotor abnormalities; delayed attainment of developmental milestones; and behavioural and intellectual abnormalities. Schizophr Res ; — ADHD symptoms in children with mild intellectual disability. Journal of Psychiatric Research 28 Maternal infection with the influenzae is also claimed to be associated with the later development of schizophrenia in the unborn child, particularly in females. Lancet Bateson G. Archives General Psychiatry 9 An alternate approach would be to vaccinate against influenza thus influencing the course and outcome of schizophrenia in the susceptible individuals. A process of selective neuronal death and progressive synaptic elimination appears to operate throughout adolescence to eliminate early errors of connection and it is suggested that this sculpting of this nervous system might be abnormal in schizophrenia. It is possible that a similar process as is occurring in these animals with early brain lesions explains why preschizophrenic children do not show the positive symptoms of schizophrenia until early adult life. Archives of General Psychiatry 43 Intellectual disability co-occurring with schizophrenia and other psychiatric illness: population-based study. The idea that severe, adult mental illness has its origins in disturbed development of the nervous system had been proposed before, 3 but new impetus was given by several lines of evidence. Neurobiological investigation in cingulated cortex of schizophrenic brain.

Rare chromosomal deletions and duplications are associated with attention deficit hyperactivity disorder and overlap with those conferring susceptibility to autism and schizophrenia. The beginning of the end for the Kraepelinian dichotomy.

Genome-wide association studies: theoretical and practical concerns. These include: slightly abnormal gaits in children; dysgraphaesthesia; proprioceptive errors; tics; twitches and epileptic attacks.

A description of the neurodevelopmental hypothesis of schizophrenia

Investigation of the temporal lobe. Biological psychiatry 35 However, such findings remain controversial and are only suggestive, not conclusive, of deviant neurodevelopment. Gunther-Genta F. It is possible it is mediated through maternal antibodies to influenzae cross-reacting with neuronal proteins, a mechanism that has been observed in rabbits or that certain mothers are genetically predisposed to produce a harmful immune response Any theory attempting to explain this association must also account for why only a minority of mothers infected with influenzae during pregnancy have a child who becomes schizophrenic. Journal of Psychiatric Research 17 Few of the positive findings supporting the neurodevelopmental hypothesis are undisputed. Can we intervene usefully at some point in the developmental cascade toward illness? Neuropathology of schizophrenia Archives of General Psychiatry 39 Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status. Biological Psychiatry 34

Schizphrenia Research 20 Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status. Journal of Nervous and Mental Disorders Feb 2 Thus, Laurens et al, 81 who examined children aged 9—12, suggested using a trilogy of antecedent markers speech or motor delays; minor psychotic symptoms; and social, behavioural, or emotional problems to identify those at sufficient risk to merit intervention.

Clearly, reducing urbanicity or migration is not within the powers of psychiatrists and minimizing childhood adversity is difficult, though not impossible.

the neurodevelopmental hypothesis of schizophrenia quizlet

Advanced Search Abstract At its re-birth 30 years ago, the neurodevelopment hypothesis of schizophrenia focussed on aberrant genes and early neural hazards, but then it grew to include ideas concerning aberrant synaptic pruning in adolescence.

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The Neurodevelopmental Hypothesis of Schizophrenia, Revisited